Would you rather play with or against an IQP?

IQP = Isolated Queens Pawn

Play against, defending and trading pieces feels easier than going for an attack and the initiative to compensate for a structural weakness

Both.
Static weakness versus dynamic edge.

'He who fears an isolated Queen's Pawn should give up Chess.' - Tarrasch

Whether you play for or against the IQP is dependent on your opening choices.
Fischer liked 1 e4 and rarely had an IQP as white. Sometimes he'd play against one as black e.g. through QGD.
Kasparov played both 1 e4 and 1 d4 and was happy with the initiative an IQP brings. He didn't mind them as black either e. g. meeting Sicilian Alapin by 2... e6 and 3... d5.
Karpov was in between, willing to accept an IQP or defend against one. He preferred the latter, e. g. Nimzoindian with c5, cxd4 and dxc4.
As white, the IQP usually gives good dynamic play and attacking chances. As black, the IQP usually gives good equalising chances. See e.g. Karpov v Korchnoi games in the French.

With. Ne5, Rook lift e3-g3/h3, Bc2/b1-Qd3-Qh7# !

@qpalzm123456 said ^

Play against, defending and trading pieces feels easier than going for an attack and the initiative to compensate for a structural weakness

I want my opponent to have static weaknesses AND dynamic ones. :)

Against it, I am a QGA player so I face IQPs a lot and it's pretty comfortable.